CTLA4 and melanoma: In contrast, enforced expression of mLama4MHC-I or mAlg8MHC-I NeoAg along with mItgb1MHC-II NeoAg rendered YUMM1.7 melanoma lines (Y1.7LI and Y1.7AI) sensitive to anti-CTLA-4 ICT (Figure 1A).