We previously reported that pharmacological inhibition of HIF-1α or HIF-2α suppressed retinal neovascularization in murine models of oxygen-induced retinopathy (OIR) [17–19], known as a retinal neovascularization model, and laser-induced CNV [20–22], known as an exudative AMD model. The gene discussed is EPAS1; the disease is age-related macular degeneration.