All subgroups were further clustered into the following groups (Figure 2D): T cells (Tcell) including c10 based on CD3D/CD3E/CD3G genes, myeloids including c14 and c15 based on VCAN/HLA-DRA/FCGR1G genes, stroma cells including c7 and c0 based on WNT3A/TUBA1A/ACTC1 genes, fibroblasts including c16 based on COL1A2/COL6A2/IGFBP4 genes, cycling cells including c6 and c8 based on TOP2A/MKI67/PTTG1 genes, and tumor cells including c1, c2, c5, c21, c11, c20, c12, c9, and c3 based on KRT7/GATA3/KRT23 genes. The gene discussed is TOP2A; the disease is neoplasm.