In this study, using an integrated analysis on bulk and scRNAseq transcriptomic datasets, we provide evidence that EMP1+/COL3A1+ fibroblasts are enriched in BoM samples of breast, prostate, and renal cancers, and these fibroblasts might contribute to the BoM process through potential COL3A1-ADGRG1 communication with cancer cells. The gene discussed is GRHL2; the disease is cancer.