Our findings likewise demonstrate the addition of myeloid cells to MiaPaCA2 spheroids upregulate the tumor secretome, activating hypoxia-related pathways and those involved in PC progression, including VEGF (vascular endothelial growth factor), Notch and TGFb (transcription growth factor beta) signaling (46). The gene discussed is TGFB1; the disease is pachyonychia congenita.