Inhibition of ERO1a or IDO1 prevented this upregulation between D5 and D8, indicating their roles in modulating myeloid cells in PC progression, Although IDO1 inhibition D5 did not downregulate proteins in these PC pathways compared to untreated D5, it downregulated 4.83-8.7% quantified proteins involved in these pathways upon myeloid cell infiltration D8. The gene discussed is IDO1; the disease is pachyonychia congenita.