To investigate alterations in the secretome by PDAC tumor spheroids upon inhibition of ERO1 or IDO1 at day 0 (TD0), supernatants from treated and untreated tumor spheroids were collected on day 5 (D5) of tumor culture and on day 8 (D8) following three days co-culture with U937 myeloid cells (Figures 1A, B, S2A). The gene discussed is IDO1; the disease is neoplasm.