In the severe ME/CFS group, those subclusters fuse to form a large cluster of positive-feedback biomarkers, and the interaction of inflammatome with immunome is observed: a correlated fused cluster of variables IFN-γ, IL-17A, IL-2, IL-21, IL-23, TNF-α, anti-M4, IgM, IgG1, IgG3, IgG4, and IgA. This evidence concerns the gene IL21 and myalgic encephalomeyelitis/chronic fatigue syndrome.