Common targets for CRC include EpCAM, carcino-embryonic antigen (CEA), epidermal growth factor receptor (EGFR), placental alkaline phosphatase (PLAP), human epidermal growth factor receptor-2 (HER-2), tumor-associated glycoprotein-72 (TAG-72), guanylate cyclase C (GUCY2C), Natural killer group 2 member D (NKG2D), and others. The gene discussed is EGFR; the disease is colorectal carcinoma.