Cytolytic CD4+ T cells have also been demonstrated to mediate potent anti-tumor effects [Hunder et al., 2008, Tran et al., 2014, Johnson et al., 2016, Rodig et al., 2018, Alspach et al., 2019, Tang et al., 2021 (46–51)]. The gene discussed is CD4; the disease is neoplasm.