VEGF is responsible for endothelial activation, endothelial growth, and angiogenesis (57), where angiogenesis is one of the key pathways for the synovial tissue expansion in RA and is accompanied by a sustained inflammatory process in the synovial tissue characterized by proinflammatory cytokines and upregulated levels of VEGF in synovial tissue (57, 58). This evidence concerns the gene VEGFA and rheumatoid arthritis.