The 10 most repressed genes were in CD4+ CM cells both in exCOPD and NSCLC samples: MAP3K2, SUZ12, SYNE2, HNRNPF, RNF24, APLP2, HIPK3, FBXL5, SEPT2, and GLCCI1. This evidence concerns the gene HIPK3 and non-small cell lung carcinoma.