The 10 most repressed genes were in CD4+ EM cells both in exCOPD and NSCLC samples: FGFBP2, CERKL, RBL2, GNLY, SYNE1, HNRNPLL, PTPN4, GLS, ITGAM, and TGFBR3. This evidence concerns the gene GLS and non-small cell lung carcinoma.