The 10 most repressed genes were in CD4+ CM cells both in exCOPD and NSCLC samples: MAP3K2, SUZ12, SYNE2, HNRNPF, RNF24, APLP2, HIPK3, FBXL5, SEPT2, and GLCCI1. The gene discussed is APLP2; the disease is non-small cell lung carcinoma.