On the other hand, it was found that knockdown of METTL3/METTL14 in CRC cells increased CD8+ T cell infiltration and promoted IFN-γ, CXCL9 and CXCL10 cytokine secretion, leading to enhanced patient’s response to anti-PD-1 therapy (67). This evidence concerns the gene PDCD1 and colorectal carcinoma.