Among these constituents, immune infiltrating cells are the primary components of TIME and include CD8+ T cells, CD4+ helper T cells, regulatory T cells (Treg), B cells, natural killer cells, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), and dendritic cells (Table 2). This evidence concerns the gene CD4 and neoplasm.