reported that ZNF320, a member of the Kruppel-like zinc finger gene family, can regulate immune cell infiltration in HCC by affecting the expression levels of related chemokines through positive regulation of METTL3 Correlations with immune checkpoint-related genes revealed that patients with high ZNF320 expression also had elevated PDL-1 expression, suggesting potentially improved anti-PDL-L1 immunotherapy efficacy (113). This evidence concerns the gene METTL3 and hepatocellular carcinoma.