Moreover, an increase in VEGF mRNAs in prefrontal cortex as well as VEGF and PKCε proteins in hippocampal CA1 capillaries and arterioles is evident (Moore et al., 2020; Wang H. et al., 2023) in ApoE4-carrier AD human brains that related with increased microinfarcts (Yip et al., 2005). The gene discussed is APOE; the disease is Alzheimer disease.