The main findings of our study can be summarized as follows: (1) α-Klotho is a superior biomarker than serum creatinine for AKI in AMI patients with eGFR ≥60 ml/min ∗ 1.73 m2, (2) Higher α-Klotho levels at admission indicates greater morbidity of CKD, and (3) with numerous studies finding α-Klotho decreased in AKI rodent models, our team firstly reported that α-Klotho increased significantly in AMI induced AKI patients, which deserves further research. Here, KL is linked to acute kidney injury.