The major risk factors for AKI were extensive anterior myocardial infarction (odds ratio [OR] = 7.525, 95% CI 1.039–54.487, p=0.046), Killip classification ≥2 grade (OR = 7.797, 95% CI 1.649–36.878, p=0.01), α-Klotho (≥516.9 pg/ml) (OR = 7.357, 95% CI 1.516–35.702, p=0.013), eGFR (decrease per 10 ml/min ∗ 1.73 m2) (OR = 1.048, 95% CI 1.006–1.091, p=0.023), Hgb (OR = 1.052, 95% CI 1.005–1.102, p=0.030), and nonuse of ACEI/ARB (OR = 5.401, 95% CI 1.148–25.414, p=0.033) (Table 4). This evidence concerns the gene KL and acute kidney injury.