Areas indicated that serum levels of α-Klotho had modest discriminative powers in prediction of AKI than creatinine (AUROC 0.792, 95% confidence interval (CI), 0.706 to 0.878, p < 0.001 and AUROC 0.583, 95% CI, 0.460 to 0.706, p=0.179). The gene discussed is KL; the disease is acute kidney injury.