Seibert et al. [22] have reported that serum α-Klotho was increased in AKI patients and progressively decreased in patients with CKD stage 1 to 5, and in this study, the etiology of AKI includes infection, parenchymal renal disease, acute tubular necrosis, prerenal kidney failure, cardiorenal syndrome (CRS), and other renal disease. This evidence concerns the gene KL and chronic kidney disease.