For the GATA4 gene, the c.1132A > G variant was considered by Orjuela et al. [26] as “polymorphism”, however, Liu et al. [27] identified this variant in a heterozygous state in 2/600 patients in a Han Chinese population that presented a clinical diagnosis of cone truncal defects (CTD), one presented Tetralogy of Fallot and another pulmonary atresia with ventricular septal defect (VSD), without being described in the control population, also indicate that Al-Azzouny et al. [28] predicted that this variant could give rise to a non-functional transcript. The gene discussed is GATA4; the disease is ventricular septal defect 1.