Interestingly, adipocyte HIF-2α deficiency exacerbates Western diet-induced atherosclerosis by increasing ceramide levels in adipose tissue, and activation of fatty HIF-2α by the HIF-PHI (Roxadustat) protects against atherosclerosis while simultaneously reducing fat, plasma ceramide, and plasma cholesterol levels (Zhang et al., 2019). The gene discussed is EPAS1; the disease is atherosclerosis.