To further identify key senescence-related DEGs for IDD, we performed LASSO regression analysis based on 26 senescence-related DEGs (Figure 4A) and obtained 12 key senescence-related DEGs, including, CABIN1, CDKN2B, CDKN2C, CXCL8, H1-5, MAP4K4, MAPK11, MDM2, MINK1, TFDP2, TINF2, and TNIK (Figure 4B). This evidence concerns the gene CXCL8 and intervertebral disk degenerative disorder.