In the qPCR results, the expression levels of CDKN2C (p < 0.01), MAP4K4 (p < 0.01), TFDP2 (p < 0.05), and TNIK (p < 0.01) in the IDD group were significantly higher compared to the control group. The gene discussed is MAP4K4; the disease is intervertebral disk degenerative disorder.