They are up-regulated in gliomas, meningiomas and prostate cancers.47–51 MCM-7 protein is found to be associated with cyclin D1-dependent kinase and may regulate the binding of this protein with the tumour suppressor retinoblastoma protein.52 MCM-7 expression has been found to predict poor clinical outcomes in various types of cancers.53–56. The gene discussed is MCM7; the disease is glioma.