In NFPA, the biomarkers that were found to be positively correlated with disease recurrence and invasion were: MCM-7 protein that has a role in the insensitivity to anti-growth signals, EGFR that modulates self-sufficiency in growth signals, and PTTG that has a role in sustained angiogenesis. The gene discussed is PTTG1; the disease is non-functioning pituitary adenoma.