INS and Other metabolic disease: DM is generally categorized into two types: type-1 and type-2, type-1 DM is a metabolic disease occurs due to autoimmune destruction of β cells of pancreas, as a result the pancreas becomes unable to produce enough or any amount of insulin to lower BGL in blood stream, this type is also known as insulin-dependent as patients of this type always need infusing exogenous insulin to survive [3].