In this regard, Beck et al. [19] recently identified a new disease entity called the VEXAS syndrome (vacuoles, E1 ubiquitin conjugating enzyme, X-linked, autoinflammation, somatic), which is caused by somatic mutations of the UBA1 gene in haematopoietic progenitor cells of older men, inflicting a range of inflammatory and haematologic symptoms. The gene discussed is UBA1; the disease is VEXAS syndrome.