Consistently, sympathetic-excitatory and pressor responses to ArcN leptin nanoinjections in rats were eliminated by local AT1aR blockade with angiotensin receptor blockers (ARBs) [99], suggesting that in obesity the antihypertensive effect of ARBs can be amplified by inhibition of the sympatho-excitatory effect of leptin. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.