Furthermore, soluble (pro)renin receptor (sPRR), a cleavage product of full-length PRR, has been suggested to be involved in intrarenal RAAS activation, ENaC expression, endothelial dysfunction and impaired baroreflex response, and might be therefore a potential target of novel pharmacological interventions for obesity-related hypertension [194]. Here, ATP6AP2 is linked to obesity due to melanocortin 4 receptor deficiency.