AGT and Insulin resistance: However, when subcutaneous fat is maximally expanded, lipids start accumulating in visceral adipocytes, a process that is considered to be involved in inflammation, oxidative stress, lipotoxicity, insulin resistance, increased production of free fatty acids, cytokines [interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α], hormones [angiotensinogen, angiotensin II (AngII), leptin and resistin] and overall worsening of the atherogenic profile [33–36].