Logistic regression analysis indicated that sclerostin in blood, even when corrected for known and potential confounders (age, sex, BMI, eGFR, serum calcium, and FGF23), was significantly associated with the status as recurrent kidney stone former and stone type, namely uric acid stones Taken together, our results indicate that sclerostin may be involved in kidney stone formation; however, independent of urinary calcium excretion. This evidence concerns the gene SOST and nephrolithiasis.