In hypercalciuric individuals, sclerostin levels were not different from normocalciuric patients, neither did sclerostin levels correlate with 25-OH Vitamin D, 1, 25OH-Vitamin D or 24-hour urinary calcium excretion, indicating that serum sclerostin might not play a major role in the pathophysiology of hypercalciuria. The gene discussed is SOST; the disease is Hypercalciuria.