However, Gurgel et al. (23) report in their study that the first case of COVID-19 in the state of Sergipe may have occurred a few months earlier, as samples from asymptomatic individuals sent for blood tests between the months of January and April 2020 by reasons unrelated to COVID-19 showed the presence of SARS-CoV-2 immunoglobulins (IgM and IgG) before the notification of clinical cases in the state. Here, CD40LG is linked to COVID-19.