In anti-myocardial hypertrophy, regulators of G-protein signaling (RGS), namely, RGS2 and RGS4, have a central role, leading to cGMP-mediated anti-myocardial hypertrophic effects by inactivating G-protein-coupled signaling, as RGS2 and RGS4 are targets of PKG (Klaiber et al., 2010). The gene discussed is RGS4; the disease is cardiac hypertrophy.