Thus, GIPC1 functions as an adaptor for loading PDZ-binding proteins as cargo onto the myosin VI motor protein, which transports various transmembrane proteins into endocytic vesicles [4,8] involved in processes such as endocytosis [6,7], angiogenesis [9], lymphangiogenesis [10], cell cycle regulation [11], and cancer metastasis [12]. The gene discussed is GIPC1; the disease is cancer.