TUNEL staining revealed that the tumor samples of MPC-11/carfilzomib cells displayed diminished staining signals compared with those of parental MPC-11 cells; in contrast, the tumor samples of MPC-11/carfilzomib cells with TNFRSF1A knockdown exhibited a significant increase in TUNEL staining signals (Fig. 8C). This evidence concerns the gene TNFRSF1A and neoplasm.