CalliSpheres DEBs is a secure treatment approach for CRCLM, but it results in a high local response rate. Hypoxia caused by embolization induces increased production of vascular endothelial growth factor (VEGF), stimulating angiogenesis. This promotes tumour recurrence. DEBIRI, in combination with angiogenesis inhibitors, may be studied in the future. Here, VEGFA is linked to neoplasm.