VEGFA and neoplasm: A similar result of significantly high MVD in left-sided CRC was reported previously within the tumor [24], and a possible explanation was that the vascular endothelial growth factor (the mediator of angiogenesis that promotes endothelial cell migration and proliferation), which is secreted by tumor cells and could be present in a minimal amount in normal mucosal tissue, was stronger and expressed more in the left-sided and rectum regions of CRC [25].