MVD: microvascular density, α-SMA: alpha smooth muscle actin, CRC: colorectal cancer, n: number, SD: standard deviation, T: tumor; T1: tumor invades submucosa (through the muscularis mucosa but not into the muscularis propria); T2: tumor invades muscularis propria; T3: tumor invades through the muscularis propria into the pericolorectal tissues; T4: tumor invades through the visceral peritoneum or adheres to other adjacent organs or structures, LN: lymph node; N1: metastasis in one to thee regional lymph nodes; N2: metastasis in four or more regional lymph nodes. This evidence concerns the gene ACTA1 and colorectal cancer.