This study aimed to estimate the MVD in tumor and adjacent tissue of CRC patients by using two IHC markers, ERG and α-SMA, the first one to stain the endothelial cells, and the second to stain the pericytes; to assess both the MVD and the mean pericytes number, then to correlate the results with general clinicopathological variables and special histopathological changes including inflammatory reaction, tumor budding, tumor deposition and lymphovascular invasion. This evidence concerns the gene ACTA1 and neoplasm.