RBL1 and small cell lung carcinoma: For the study of small-cell lung cancer (SCLC), Sánchez-Rivera et al. (2014) injected into mice transgenic for p53flox/flox and Rb1flox/flox two constructs, one containing Cas9 and Csy4 (an RNA endonuclease) and another carrying sgRNA against p107 and p130 and CRE [20].