To comprehensively understand the differences of tumor cells, cells in the TME in PTC of different state, we chosen the scRNA-seq data from 7 primary tumors which can represent the tumor evolution: intrathyroidal tumor (PTC9), extrathyroidal extension (PTC1), lateral neck metastasis (PTC2 and PTC3), extrathyroidal extension and lateral neck metastasis (PTC8), and distant metastasis (PTC5 and PTC10). Here, NCOA4 is linked to neoplasm.