To reveal the downstream genes regulated by CREB1 in our study, we employed Wayne (Venn) analysis to obtain the intersections between up‐regulated DEGs in CM and EC cells treated with CPPs‐Exo, and four other gene lists, which were CREB1 potential target genes in hESC, cancer cells, the CHEA database and the JASPAR database. The gene discussed is CREB1; the disease is cancer.