Inspired by the paper showing that SIK1 phosphorylates and deactivates CRTC1 (CREB‐regulated transcription coactivator 1),40 resulting in a decrease in CREB1 transcriptional activity,41 we looked for potential genes downstream of the SIK1‐CREB1 axis by Venn analysis to compare six gene lists (up‐DEGs in CM or EC transfected by miR‐27b‐3p mimics, predicted genes regulated by CREB1 in cancer cells, or hESC, or in the CHEA database or JASPAR database) and finally found the gene Gpx4 (Figure 7L). This evidence concerns the gene CREB1 and cancer.