PCSK9 and Sepsis: Moreover, sepsis intricacies differ across species, leading to skepticism about the universal applicability of rodent sepsis models.238 It is worth noting that rodents are significantly more resistant to sepsis than humans, although humanized mouse sepsis models have been developed to somewhat counter this limitation.239 Furthermore, while PCSK9-iTs may improve survival rates for adult sepsis patients, children or infants with sepsis might not benefit from PCSK9-iTs since PCSK9 LOF has been linked to poor survival in young mice and children.