PCSK9 and malaria: However, they lack the innate capability to synthesize cholesterol, therefore, they source it from their hosts.246 In a study of 752 Malian children, Arama et al. reported that the children possessing PCSK9 GOF mutations were susceptible to a more severe disease trajectory of malaria,247 whereas Fedoryak and colleagues revealed that PCSK9 LOF mutations were linked to a decrease in malaria-related mortality.248 These findings give rise to the proposition that PCSK9-iTs could potentially serve as therapeutic and preventive measures for malaria.