For instance, the adnectin BMS-962476 efficaciously blocked PCSK9’s biological function by averting its binding and co-internalization with LDLR, thereby reinstating LDLR recycling and amplifying the absorption of LDL in HepG2 liver cancer cells.448 PS, a γ-lactam alkaloid sourced from the fungus Aspergillus fumigatus, demonstrated not just the useful properties against inflammation and seizure, but also the ability to inhibit PCSK9. This evidence concerns the gene PCSK9 and liver cancer.