For instance, the adnectin BMS-962476 efficaciously blocked PCSK9’s biological function by averting its binding and co-internalization with LDLR, thereby reinstating LDLR recycling and amplifying the absorption of LDL in HepG2 liver cancer cells.448 PS, a γ-lactam alkaloid sourced from the fungus Aspergillus fumigatus, demonstrated not just the useful properties against inflammation and seizure, but also the ability to inhibit PCSK9. The gene discussed is LDLR; the disease is liver cancer.