This ailment is typically linked with heightened expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and elevated antibodies against HMGCR levels.291,292 However, in a mouse model of experimental autoimmune encephalomyelitis (EAE), Alirocumab application appeared to have no effect on EAE progression or immune response, implying that blood cholesterol levels may not directly affect neuro-inflammatory diseases and that the protective benefits of statins may not be related to levels of circulating cholesterol.293. The gene discussed is HMGCR; the disease is experimental autoimmune encephalomyelitis.