Further, NAFLD has the potential to advance into NASH, typified by inflammation, and eventually to cirrhosis, which is a substantial risk factor for hepatocellular carcinoma (HCC).180 There are suggestions of an association between PCSK9’s role in TG metabolism at the intestinal level and the NAFLD pathogenesis due to its plasma concentration.181,182 Recent discoveries have underscored the significance of PCSK9 in managing liver lipid balance.183. The gene discussed is PCSK9; the disease is metabolic dysfunction-associated steatohepatitis.