Over the ensuing two decades, we have witnessed substantial strides in unraveling the complexities of PCSK9’s biological features as well as its involvement in an array of physiological and pathological activities ranging from cholesterol homeostasis, cancer biology, to immunology, including but not limited to CVDs, liver diseases, infectious diseases, autoimmune disorders, neurocognitive disorders, and malignancies.84,498 PCSK9 operates as a navigator, shepherding specific surface protein receptors to degrade in cytosolic endosomes and/or lysosomes. This evidence concerns the gene PCSK9 and autoimmune disease.