However, the involvement of PCSK9 in inflammatory activities can still remain debatable due to inconclusive results from clinical studies regarding PCSK9-iTs’ effects on inflammation markers and the inconsistent relationship between PCSK9 concentrations and the evolution of atherosclerosis in the general population.43,72,171–175 More research is warranted to fully examine PCSK9’s role in bridging cholesterol and inflammation and the scope of its cholesterol-independent regulatory function during inflammation.176–178. The gene discussed is PCSK9; the disease is atherosclerosis.