Additionally, our earlier Kaplan-Meier survival analyses using TCGA datasets displayed a significant correlation between high PCSK9 mRNA expression and poor OS in various common types of cancer, such as LIHC, pancreatic adenocarcinoma (PAAD), skin cutaneous melanoma (SKCM), bladder urothelial carcinoma (BLCA), LUAD, and ovarian serous cystadenocarcinoma (OV).34 These findings suggest that PCSK9 may have a crucial role in carcinogenesis, and a significant number of cancer patients could potentially benefit from PCSK9-iTs. This evidence concerns the gene PCSK9 and pancreatic adenocarcinoma.