PCSK9 and cardiovascular disorder: Increased oxLDL levels are associated with RA and are linked to cardiovascular diseases in RA.279–281 The induction of immune inhibitory Tregs is generally considered beneficial in RA.282 Hence, if oxLDL plays a role in RA, the ways in which PCSK9 mitigates oxLDL’s proinflammatory and immune-activating properties could be relevant to this disease.