PCSK9 and esophageal cancer: Intriguingly, esophageal cancer patients manifesting high levels of anti-PCSK9 antibodies demonstrated a superior prognosis after surgery.337 In the context of GC, a quantitative proteomic study utilizing stable isotope labeling by amino acids in cellular culture displayed a 13-fold augmentation in PCSK9 expression in the secretome of GC, when compared with non-neoplastic gastric epithelial tissue.