This implied PCSK9’s protective role in preventing HCV’s infectious activities in Huh-7.5.1 HCC cells.202 Moreover, patients suffering from chronic infection of HCV genotype 3 (HCV-G3) displayed lower concentrations of blood PCSK9 and LDL-C, likely due to enhanced LDLR activities. Here, PCSK9 is linked to hepatocellular carcinoma.