Upon exposure to the liver carcinogen diethylnitrosamine, PCSK9KO mice on HCD exhibited a greater propensity to develop liver cancer in comparison to their WT counterparts.186 Further, Yang et al. reported that PCSK9-iTs could notably inhibit the stem-like properties of HNSC cells, an effect that is dependent on the presence of LDLR.358 Therefore, further investigation is necessary to demonstrate the potentially critical role of PCSK9 in carcinogenesis and apoptosis, especially for liver cancer. The gene discussed is LDLR; the disease is liver cancer.