APC and colorectal carcinoma: An extensive analysis of 843 CRC patients by Tao et al. identified PCSK9 as one of the five differentially expressed genes (DEGs) showing upregulation in CRC samples.341 Further, in a study focused on the APC Regulator Of WNT Signaling Pathway/KRAS Proto-Oncogene, GTPase (APC/KRAS)-mutant CRC, a particularly therapy-resistant subtype of CRC, Wong et al. also identified PCSK9 as the top upregulated cholesterol-related gene.