PCSK9 and Sepsis: Remarkably, PCSK9KO mice showed resistance to septic shock caused by LPS exposure,227 whereas PCSK9 LOF variants were associated with fewer instances of septic shocks and organ failures,228,229 unlike the scenario in those transgenic mice with high levels of PCSK9 expression.230 Further, the LDLR is known to rid the system of gram-positive lipoteichoic acid as well as gram-negative LPS, which are identified pathophysiological exacerbators for sepsis, through an LDL-dependent manner.231