PCSK9 and melanoma: They further illustrated that PCSK9 promoted the proliferation and migration of B16 mouse melanoma cells along with their growth in vitro and tumor formation in C57BL/6 mice.375 Further, PCSK9-iT showed synergistic effects with anti-PD-1 treatment in mouse models, as did treatments with either anti-PCSK9 mAbs (Evolocumab and Alirocumab) or genetic deletion.