TGFB1 and Hepatic fibrosis: The interplay between Wnt and TGF-β signaling pathways has been established in liver fibrosis, but as for its relevance to liver I/R in terms of TGF-β-related treatment approaches, Zhang et al. observed an upregulation of Wnt3a, β-catenin, VEGF, and Cyclin D1, as well as a downregulation of GSK-3β and caspase 3 in a rat model of MCAO following isoflurane injection.