Research has shown that under conditions of cerebral ischemia and hypoxia, the HIF-1α signaling pathway is activated.347 The upregulated HIF-1α signaling pathway can induce the activation of the Wnt/β-catenin signaling pathway, promoting the proliferation of neural stem cells and neuronal differentiation226 (Fig. 8c). The gene discussed is HIF1A; the disease is Cerebral ischemia.