After hepatic ischemia or reperfusion, the expression level of β-catenin regulates the activity of the HIF-1α signal,274 and the lack of β-catenin leads to the inhibition of HIF-1α signal transduction after hepatocyte hypoxia.274 Under hypoxia or H/R conditions, HIF-1α can competitively inhibit the interaction between TCF4 and β-catenin, which enhances HIF-1α signal transduction, reduces apoptosis, and promotes cell survival.274,349 Furthermore, Crosstalk between HIF and Wnt/β-catenin signaling pathway has also been reported in renal I/R. Here, HIF1A is linked to ischemia.