The PI3K/Akt signaling pathway, named after its key components, phosphatidylinositol 3-kinase (PI3K) and AKT (also known as protein kinase B, PKB), plays a crucial role in regulating cell proliferation, survival, and apoptotic processes.326 Crosstalk between the PI3K/Akt and Wnt signaling pathways influences osteoblast proliferation, differentiation, and cancer development.327 The PI3K/Akt/Wnt signaling crosstalk has been identified as a critical pathological process in I/R injury of the heart, brain, and liver, impacting apoptosis and angiogenesis. Here, AKT1 is linked to cancer.