BDNF and ischemic stroke: Cyclin D1227 and Pax6228 promote neural stem cell proliferation, Neuro D1 promotes adult neurogenesis and maintains neuronal survival,229,230 and Ngn2 promotes neurogenesis.231 Additionally, Wnt/β-catenin signaling activates BDNF secretion from glial cells and protects adjacent neurons.232 Overall, this upregulation of BDNF by Wnt/β-catenin signaling contributes to nerve repair during an ischemic stroke by promoting neurogenesis and neuronal survival.233