ACTA1 and Cerebral ischemia: NMDAR is an important ion channel for excitatory synaptic transmission, and ActA regulates synaptic plasticity through NMDAR phosphorylation activation and Ca2+ influx.407 Recent studies have highlighted the interplay between the NMDAR-Ca2+-ActA and Wnt/β-catenin signaling pathways in regulating synaptic plasticity during cerebral ischemia.407