Jin et al. observed a significant increase in proliferation-related Ki-67 antigen-positive cells in the ischemic penumbra in the autopsy brain tissue of adult patients with ischemic stroke, alongside the expression of neuronal lineage doublecortin, tOAD/Ulip/CRMP family protein 4, and βIII tubulin.224 Another study demonstrated that cell proliferation was active in the SVZ region in elderly patients who died of ischemic stroke;225 which indicated that cerebral ischemic injury-induced adult neurogenesis is possible. This evidence concerns the gene DCX and ischemic stroke.