VEGFA and brain ischemia: During cerebral ischemia, transplanted oligodendrocyte precursor cells secrete Wnt7a in a paracrine manner; Wnt7a can activate EC Wnt/β-catenin signaling and promote angiogenesis and neurological recovery.244 Alternatively, isoflurane postconditioning (inhalation of 1.5% isoflurane for 60 minutes after reperfusion) can activate the Wnt/β-catenin signaling pathway and promote the expression of target protein VEGF,170 which may promote angiogenesis.