NOS2 and ischemia: Wnt/β-catenin signaling is activated by the inflammatory response during ischemia.119 Sun et al. demonstrated that the malondialdehyde content and Fe2+ concentration in the hearts of mice significantly increased following MI, while the expression of ischemia-susceptibility marker NOS2 was upregulated and that of the M2-polarization marker IL-10 was downregulated in macrophages.