By analysing ChIP-seq data for SP1, SP2, and SP5 in the liver cancer cell line HepG2 (downed from ENCODE) [36], we found direct binding of SP1, SP2, and SP5 to the promoters of most SRTs near TSSs, which exhibited strong H3K27ac occupancy and open chromatin accessibility (Fig. 3h and Fig. S3d). This evidence concerns the gene SP5 and liver cancer.