SP1 and liver cancer: By analysing ChIP-seq data for SP1, SP2, and SP5 in the liver cancer cell line HepG2 (downed from ENCODE) [36], we found direct binding of SP1, SP2, and SP5 to the promoters of most SRTs near TSSs, which exhibited strong H3K27ac occupancy and open chromatin accessibility (Fig. 3h and Fig. S3d).