We found that spliced genes with novel isoforms were strongly associated with key pathways in HCC, which were overrepresented, including replication (Myc targets and G2M checkpoint pathway), NF-κB signalling, mTORC1 signalling, and Wnt signalling pathways et al. (Fig. 2d). Here, NFKB1 is linked to hepatocellular carcinoma.