Since Hani et al. discovered that tRFs derived from tRNA-Glu, tRNA-Asp, tRNA-Gly, and tRNA-Tyr competitively bind to the endogenous oncogene YBX1 in BC cells, inhibiting cell growth by interfering with oncogene transcription stability, the role and mechanism of tsRNAs in BC occurrence and development have been extensively explored [15]. The gene discussed is YBX1; the disease is breast cancer.