Cytokines and chemokines in TME, such as CSF1, GM-CSF, IL-1β, CCL2, and VEGF, can induce conformational changes in α4β1 integrins to promote myelopoiesis, monocyte-to-tumor trafficking, and infiltration by activating the corresponding signaling pathways [14, 67]. Here, VEGFA is linked to neoplasm.