IFNA1 and cancer: A recent review of scRNA-seq cancer studies noted that certain subsets of TAMs are retained in almost all cancer types, and Ruo-Yu Ma et al. classified these TAMs into seven subgroups based on their signature genes, enrichment pathways, and predicted functions, naming them interferon-stimulated (IFN-TAMs), immune-modulated (Reg-TAMs), inflammatory cytokine-enriched (Inflam-TAMs), lipid-associated (LA-TAMs), pro-angiogenic (Angio-TAMs), RTM-like (RTM-TAMs), and proliferative TAMs (Prolif-TAMs) (Fig. 1d; Table 1).