STAT3 and neoplasm: In turn, M2-like TAMs facilitate tumor angiogenesis by secreting growth factors such as VEGF and TGF-β; immunosuppressive factors like IL10; factors that activate the self-renewal and proliferation of tumor stem cells, such as IL-6 and STAT3; and proteases that alter the extracellular microenvironment, like matrix metallopeptidases, to encourage tumor progression [86].