Consequently, reduced expression of miR-92a suppressed CRC cells’ stemness by decreasing the spheroid formation ability of these cells and downregulating stemness-related proteins, including p-AKT and p-STAT3, suggesting that the downregulation of p-AKT and p-STAT3-mediated by miR-92a and the suppression of self-renewal and growth in SW480 and LoVo CSC cells could be achieved by SOCS3 overexpression [72]. Here, AKT1 is linked to colorectal carcinoma.