In our study, we found that MCC950, an inhibitor of NLRP3 which could attenuate the severity of experimental autoimmune encephalomyelitis, could significantly alleviate the cardiac inflammatory, cardiac function and arrythmia of Dsg2mut/mut mice exhibiting better biventricular function, less left ventricular diameter, and less proinflammatory CCL3+ macrophage infiltration (Fig. 6). The gene discussed is NLRP3; the disease is experimental autoimmune encephalomyelitis.