The NLRP3 inflammasome is a macromolecular platform that senses tissue injury and, in response, processes active IL-1β (upregulation in CCL3+ MPs) and IL-18, two major proinflammatory cytokines, and could induce an inflammatory form of cell death termed pyroptosis, participating in inflammatory disease such as Alzheimer disease, inflammatory bowel disease, experimental autoimmune encephalitis, myocardial infarction, and so on [48]. The gene discussed is IL1B; the disease is early-onset autosomal dominant Alzheimer disease.