In a larger cohort consisting of 243 patients with HCC, TP53, CTNNB1, AXIN1, ALB, ARID1A, ARID2, ACVR2A, NFE2L2, RPS6KA3, KEAP1, RPL22, CDKN2A, CDKN1A, and RB1 were identified as driver genes for HCC [30]. The gene discussed is RPL22; the disease is hepatocellular carcinoma.