We retrieved the data of aforementioned frequently mutated genes in HCC-ZJ, and observed several nonsynonymous single nucleotide variant (SNV) sites in TP53, CTNNB1, ARID1A, NFE2L2, and CDKN1A (Table 3), as well as several frameshift INDELs in TERT, ARID1A, CDKN2A, SMARCA2, HGF, TP53, RAC2, ALB, ARID1A, ARID2, ACVR2A, and RB1 (Table 4). Here, RB1 is linked to hepatocellular carcinoma.