For example, mutations of TERT (60%), CTNNB1 (37%), ARID1A (13%), CDKN2A (9%), SMARCA2 (3%), and HGF (3%) were significantly associated with the history of alcohol abuse, while the mutation of TP53 and IL6ST frequently occurred in HCC patients with HBV history [30]. This evidence concerns the gene CDKN2A and hepatocellular carcinoma.