In DLBCL with IGH::MYC, the breakpoint commonly occurs in region spanning the 5’UTR and intron 1 of the MYC gene and the switch region of the IGH locus respectively, thus placing the MYC gene in close proximity of the highly active IGH super enhancer, causing MYC constitutive over-expression [13]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.