Based on COO, DLBCL can be broadly classified into activated B-cell like (ABC) and germinal centre B-cell like (GCB) subtype, with a subset of the latter further identified as molecular high grade (MHG)/double-hit signature (DHITsig) due to their enriched MYC expression and centroblast signatures [1, 2]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.