The present study reports several significant novel findings, and they include: (1) MYC and BCL6 translocation in a significant proportion of DLBCL, particularly those with MYC/BCL2/BCL6-TH, are due to a direct juxtaposition between the MYC and BCL6 loci, rather than being an independent event; (2) MYC protein expression is uniformly high in DLBCL with IG::MYC, but varies in those with non-IG::MYC, including BCL6/MYC fusion; (3) MYC translocation with non-IG partner may not always acquire a genomic configuration that enables MYC constitutive transactivation, resulting in high MYC expression. Here, BCL6 is linked to diffuse large B-cell lymphoma.