Such super-enhancer mediated transcriptional activation, unlike promoter substitution, is independent of the genomic orientation of the MYC and IG genes and to a certain extent also of the “linear” distance between the two genes [22], thus explaining the uniform high MYC protein expression seen in DLBCL with IG::MYC, and also Burkitt lymphoma. This evidence concerns the gene MYC and Burkitt lymphoma.