To examine how the combined expressions of PLK1-NUMB, NOTCH-NUMB, PLK1-N-cadherin and PLK1-E-cadherin affect overall survival (OS) of melanoma patients, we downloaded the RNA-Seq gene expression and clinical data for a total of 479 patients from The Cancer Genome Atlas (TCGA) melanoma data set21. The gene discussed is CDH2; the disease is melanoma.