FCGR3A and malaria: After a Phase II trial showing that vaccination with RTS,S (based on the P. falciparum circumsporozoite protein, PfCSP) protects against P. falciparum infection in malaria-naïve volunteers40, multivariate analysis revealed that FcγRIIIa and antibody-dependent cellular phagocytosis (ADCP) were the strongest correlates of protection in a sporozoite-based CHMI41.