FBXO5 and neoplasm: We next assessed the presence of small tumor foci through immunofluorescent staining of Δ16HER2 and confirmed that, already at 11 W, Δ16HER2/EMI1 KO group of mice displayed a significantly higher number and larger size of tumor foci in comparison to the Δ16HER2/EMI1 WT group (Fig. 4i–k).