We identified a de novo variant (PRPF31:c.-9+1G>T) in the same 5’UTR position of PRPF31 in a sporadic case with rod-cone dystrophy in which bi-allelic GRM6 variants had been identified, one of them reported as likely benign (Additional file 1: Table S15). The gene discussed is PRPF31; the disease is Rod-cone dystrophy.