Besides, PCOS is characterized by a shift from an anti-inflammatory M2 to a proinflammatory M1 state, yet, our finding of opposite connection of CXCR2 and LMNB1 with macrophage M1 indicated that the signature genes and the cell in PCOS need to be further clarified [35]. Here, CXCR2 is linked to polycystic ovary syndrome.