We also noted significantly increased levels of tau protein in bulbar onset of ALS (ALS bulbar onset median 302.5 ng/l in CG median 177.5; p = 0.012 post hoc test) and limb onset of ALS (ALS limb onset median 323.5 ng/l vs CG median 177.5 ng/l; p < 0.0001 post hoc test) and also p-tau protein in bulbar onset of ALS (ALS bulbar onset median 52.7 ng/l vs CG median 29 ng/l; p = 0.005 post hoc test) and limb onset of ALS (ALS limb onset median 41.2 ng/l vs CG median 29 ng/l; p = 0.027 post hoc test) compared to the control group. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.