Following the statistical analysis, it was observed that individuals with ALS exhibited higher levels of clusterin (median 2148 μg/l in ALS vs. median 1987.5 μg/l in the control group; p = 0.038, Mann–Whitney U-test), tau protein (median 323.5 ng/l in ALS vs. median 177.5 ng/l in the control group; p < 0.0001, Mann–Whitney U-test), and phosphorylated tau protein (median 43.85 ng/l in ALS vs. median 29 ng/l in the control group; p = 0.001, Mann–Whitney U-test) in their CSF compared to the control group. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.