MAPT and amyotrophic lateral sclerosis: In our study, we noted significantly increased levels of tau protein (ALS median 323.5 ng/l vs CG median 177.5 ng/l; p < 0.0001 Mann–Whitney U-test) and p-tau protein (ALS median 43.85 ng/l vs CG median 29 ng/l; p = 0.001 Mann–Whitney U-test) in ALS patients compared to CG.