Considering extremely unbalanced variables, including hypertension, diabetes, hyperlipidemia, CYP3A4 enzyme inhibitors/inducers/competitive substrates, CYP2D6 enzyme inhibitors/competitive substrates, and variables with a missing rate greater than 50%, including weight, height may influence the predicted results of quetiapine, we preprocessed the obtained data before determining the significant associations between univariates. This evidence concerns the gene CYP3A4 and Hypertension.