CTSZ and pulmonary arterial hypertension: These demonstrated a trend towards hypermethylation at the CTSZ CpG cg04917472 (p-value = 0.0773), most clear in heritable PAH (HPAH) cases, thus providing a consensus between DNAme levels in our data and a PAH-relevant cell type (p = 0.0311 HPAH vs controls, Supplementary Fig. 12).