BMP10 and pulmonary arterial hypertension: For 16 established genes underlying heritable PAH and catalogued by Southgate et al.19, we checked the methylation profile of PAH individuals versus controls to define a CpG marker (cg10976975) within the 5’ untranslated region of BMP10 showing elevated methylation in PAH (Supplementary Data 5, Supplementary Fig. 8) with a Q-value of 0.0013 (OR [95%CI] = 1.26[1.14–1.38]).