As an anti-TNF-α antibody is clinically utilized to block the activity of TNF-α for the treatment of RA’s joint swelling and other inflammatory symptoms35, CIA rats treated with purified anti-rat TNF-α antibody (aTNF-α), and mixture of DS and aTNF-α (DS+aTNF-α) at 1 mg kg−1 of aTNF-α and 1 mg kg−1 of DS served as the control groups. This evidence concerns the gene TNF and rheumatoid arthritis.