To test this hypothesis, we performed high-throughput RNA-sequencing analysis using RNA isolated from control cell and circPPAP2B knockdown ccRCC cells, as well as RNA isolated from anti-HNRNPC RIP assay of control cell and circPPAP2B knockdown ccRCC cells (Supplementary Table 4 and 6). The gene discussed is HNRNPC; the disease is nonpapillary renal cell carcinoma.