Indeed, studies presented here revealed that HNRNPC recruits splicing factors, PTBP1 and HNRNPK, to regulate pre-mRNA alternative splicing events in ccRCC, including the alternative splicing of CD44, a critical cell-surface glycoprotein involved in cell adhesion and metastasis. The gene discussed is PTBP1; the disease is nonpapillary renal cell carcinoma.