A large meta-analysis of genetic association studies assessing the effects of cholesterol-lowering variants in or near Niemann-Pick C1-like 1, HMGCR, and LDL receptor showed an overall increased risk of diabetes with an OR of 1.19–2.42 for every 1 mmol/L reduction in LDL-C [40]. The gene discussed is HMGCR; the disease is diabetes mellitus.