Participants with higher TyG index, TyG-WC, TyG-WHtR, and TyG-BMI were more likely to be male, older, to have a higher physical activity level, and to be higher levels of BMI, waist circumference, triglycerides, fasting glucose, glycated hemoglobin, systolic blood pressure, insulin, cholesterol, self-reported cancer, self-reported diabetes, cardiovascular diseases mortality, cardiovascular disease, congestive heart failure, myocardial infarction, angina pectoris, and coronary heart disease, and lower levels of educational strata, income, and AHEI. The gene discussed is INS; the disease is cancer.